Extensions of the model and specific applications
Bronchial clearance
Hofmann, W., Sturm, R. Stochastic model of particle clearance in human bronchial airways. J. Aerosol Med. 17, 73-89 (2004).
Three-dimensional model
Hofmann, W., Sturm, R., Fleming, J.S., Conway, J.H., Bolt, L. Simulation of three-dimensional particle deposition patterns in human lungs and comparison with experimental SPECT data. Aerosol Sci. Technol. 39, 771-781 (2005).
Surface deposition density
Hofmann, W., Winkler-Heil, R, Balashazy, I. The effect of morphological variability on surface deposition densities of inhaled particles in human bronchial and acinar airways. Inhal. Toxicol. 18, 809-819 (2006).
Aerosol bolus dispersion
Hofmann, W., Pawlak, E., Sturm, R. Semi-empirical stochastic model of aerosol bolus dispersion in the human lung. Inhal. Toxicol. 20, 1059-1073 (2008).
Non-spherical particles
Hofmann, W., Morawska, L., Winkler-Heil, R., Moustafa, M. Deposition of combustion aerosols in the human respiratory tract: Comparison of theoretical predictions with experimental data considering non-spherical shape. Inhal. Toxicol. 21, 1154-1164 (2009).
Coagulation of high aerosol concentrations
Pichelstorfer, L., Winkler-Heil, R., Hofmann, W. Lagrangian/Eulerian model of coagulation and deposition of inhaled particles in the human lung. J. Aerosol Sci. 64, 125-142 (2013).
Hygroscopic growth
Winkler-Heil, R., Ferron, G., Hofmann, W. Calculation of hygroscopic particle deposition in the human lung. Inhal. Toxicol. 26, 193-206 (2014).
Lobe-specific deposition
Winkler-Heil, R., Hussain, M., Hofmann, W. Predictions of inter- and intra-subject lobar deposition patterns of inhaled particles in a five-lobe lung model. Inhal. Toxicol. 33, 96-112 (2021).
Intersubject variability
Hofmann, W., Asgharian, B., Winkler-Heil, R. Modeling intersubject variability of particles deposition in human lungs. J. Aerosol Sci. 73, 219-235 (2002).
Lung diseases
Balashazy, I. et al. Aerosol drug delivery optimization by computational methods for the characterization of total and regional deposition of therapeutic aerosols in the respiratory system. Curr. Comput. Aided-Drug Des. 3, 13–32 (2007).
Sturm, R., Hofmann, W. Stochastic simulation of alveolar particle deposition in lungs affected by different types of emphysema. J. Aerosol Med. 17, 357-372 (2002).
Füri, P. et al. Comparison of airway deposition distributions of particles in healthy and diseased workers in an Egyptian industrial site. Inhal. Toxicol. 29, 147–159 (2017).
Radon lung dosimetry
Füri, P., Farkas, Á., Madas, B.G. et al. The degree of inhomogeneity of the absorbed cell nucleus doses in the bronchial region of the human respiratory tract. Radiat Environ Biophys 59, 173–183 (2020).
Hofmann, Werner & Winkler-Heil, Renate. (2011). Radon lung dosimetry models. Radiation protection dosimetry. 145. 206-12. 10.1093/rpd/ncr059.
Cigarette smoke deposition (particles and vapours)
Lukas Pichelstorfer, Renate Winkler-Heil, Michael Boy, Werner Hofmann, Aerosol dynamics simulations of the anatomical variability of e-cigarette particle and vapor deposition in a stochastic lung, Journal of Aerosol Science, Volume 158, 2021, 105706, ISSN 0021-8502